tai game ban trung da crack sms My laboratory is focused on infectious diseases, especially human Tuberculosis caused by Mycobacterium tuberculosis (Mtb), which is one of mankind’s most successful intracellular pathogens.
BACKGROUND and RESEARCH
crash bandicoot para pc gratis en español 1 link Knowing that the mycobacterial cell envelope is one of the first links in the host-pathogen cross-talk, I did a Ph.D, in Toulouse (France), in order to study the biogenesis of the mycobacterial cell wall, especially the identification of the glycosyltransferases potentially involved in the biosynthesis of (lipo) polysaccharides which constitute the Achilles’ hill of the mycobacterial cell-envelope.
how to repair crack in plastic bucket Then, I performed my first post-doctoral project, in Toulouse (France), on the development of non-peptide-based vaccines, using glycolipids-based mycobacterial. During my second post-doctoral project, at MRC-NIMR London (UK), I focused on the “functional annotation” of orphan enzymes in Mtb with the aim of placing previously uncharacterized proteins into specific metabolic pathways by applying an activity-based metabolomic profiling technique. With this methodology we discovered a novel pathway involved in the catabolism of the polar head group of plasma membrane glycerophospholipids. In addition, as part of a collaborative project, we have found that aspartate is required for the virulence of Mtb within the host. Using the same approaches, we have also confirmed that ansP2 encodes an asparagine transporter in Mtb. Asparagine is not only assimilated by Mtb but also hydrolysed by the asparaginase AnsA resulting in the production of ammonia, which aids in the neutralization of phagosomal acidification.
nbc heads up poker crack As a lecturer in Molecular Microbiology at the MRC-CMBI, Imperial College, my laboratory explores deciphering the environmental adaptation of Mtb within the host. Mainly Metabolomics, and Transcriptomics, Proteomics, and Lipidomics are used as tools for the read-out of the first steps in this adaptation. Effectively, the success of Mtb as a pathogen partially results from its capacity to invade, survive and persist within intracellular phagosomes and extracellular sites in many host tissues. Throughout the cycle of infection, Mtb encounters and survives in a variety of harsh environments in the human body including nutrient-poor, acidic, oxidative, nitrosative and hypoxic niches. Very little is known about the molecular mechanism and kinetics of adaptation of Mtb during the first stages of infection within the host. Deciphering these mechanisms in such defined environments is crucial to understanding the physiology of Mtb within the host and can also inform on us why Mtb is such an efficient intracellular pathogen. The findings will potentially lead to the discovery of new drug targets and have a better understanding on resistant bacteria in context of the host.
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como instalar router keygen en xperia play Larrouy-Maumus G, Puzo G, 2015, Mycobacterial envelope lipids fingerprint from direct MALDI-TOF MS analysis of intact bacilli, Tuberculosis, Vol:95, ISSN:1472-9792, Pages:75-85
sonar 8.5 keygen free rust cracked server list march 2014, 2013, Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis, Proceedings of the National Academy of Sciences of the United States of America, Vol:110, ISSN:0027-8424, Pages:11320-11325
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