Imperial College London

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yahoo live cricket score india vs pakistan 2nd odi Non-Clinical Lecturer in Molecular Microbiology
 
 
 
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Summary

 

Summary

pes 2014 android crack Lecturer in Molecular Microbiology

videos de como se ase el crack My research focuses on determining the molecular basis of treatment refractory infections and the development of novel therapeutic approaches to overcome antibiotic resistance and tolerance. Specifically, I am engaged in research that follows four main themes:

  1. Molecular mechanisms of host adaptation and the evolution of antibiotic resistance. During the course of infection, Staphylococcus aureus frequently acquires mutations that enhance host adaptation or decrease antibiotic susceptibility. We have identified several genes in which mutations influence bacterial susceptibility to antibiotics, including the Agr quorum-sensing system. In particular, we have identified a novel mechanism of antibiotic resistance that enables S. aureus to survive exposure to daptomycin, a treatment of last resort for MRSA infections.
  2. Molecular basis of bacterial survival in the host. S. aureus is a frequent cause of serious infections in both humans and animals, including infective endocarditis and bovine mastitis. We are currently engaged in studies to determine the host and bacterial factors that contribute to pathogen survival during infection.
  3. Regulation of antibiotic tolerance. Despite the frequent difficulty associated with clearing staphylococcal bone and joint infections, almost nothing is known about the mechanisms by which S. aureus evades killing by antibiotics to which it is deemed susceptible via laboratory testing. We have identified a key role for global regulatory elements and putative effectors that modulate the antibiotic tolerance of S. aureus in the host environment.
  4. Novel approaches to overcoming antibiotic resistance. We are developing new antibiotics to selectively target resistant organisms, without damaging the microbiome.

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Publications

Journals

windows 7 professional k keygen keygen przyspiesz komputer chomikuj Krishna A, Holden MTG, Peacock SJ, jodix video mp3 extractor keygen, 2018, Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility., Microbiology, Vol:164, Pages:1189-1195

bubble mania cracked ipa crack nugen Sabnis A, Ledger EVK, Pader V, might and magic x crack, 2018, Antibiotic interceptors: Creating safe spaces for bacteria, Plos Pathogens, Vol:14, ISSN:1553-7366

crack grid 1.3 Pader V, Edwards AM, 2017, Daptomycin: new insights into an antibiotic of last resort, Future Microbiology, Vol:12, ISSN:1746-0913, Pages:461-464

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folder lock 7.1.8 crack file Ledger EVK, Pader V, Edwards AM, 2017, Enterococcus faecalis and pathogenic streptococci inactivate daptomycin by releasing phospholipids, Microbiology-sgm, Vol:163, ISSN:1350-0872, Pages:1502-1508

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